Abstract
Sir .—Neonatal diabetes mellitus (DM) is uncommon and usually presents with hyperglycemia, glucosuria, significant dehydration, and small size for gestational age. 1 The transient form of neonatal DM usually resolves in weeks to months. 1 The origin of the much rarer, permanent form of neonatal DM remains unclear. In older children DM usually results from autoimmune destruction of the pancreas as reflected by the presence of islet cell antibodies. However, islet cell antibodies have not been detected in neonates with DM. 2,3 Neonates having both pancreatic exocrine and endocrine insufficiency are rarer still. Winter and colleagues 4 diagnosed congenital pancreatic hypoplasia in two brothers who presented with neonatal DM and subsequently developed pancreatic exocrine insufficiency at ages 5 and 21 years. Previously pancreatic agenesis was considered fatal. 5,6 However, a report by Howard and colleagues 7 described the survival of an infant with permanent neonatal DM who was found to have
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
