Abstract
The incidence of perivillous deposition of fibrin was studied in a series of 715 placentas. It was found that the lesion occurred more commonly in placentas from uncomplicated pregnancies than in those from cases of pre-eclamptic toxemia or hypertension. Perivillos fibrin deposition was without deleterious effect on the well-being of the fetus, and babies in whose placentas this lesion was present had an unduly low incidence of neonatal asphyxia. Perivillous fibrin deposition was unrelated to fetal arterial disease or villous syncytial degeneration. It is concluded that perivillous deposition of fibrin is the result of eddy currents in the maternal blood of the intervillous space, and that the greater the maternal flow through the placenta the more likely is it that plaques of perivillous fibrin will be formed.
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