Abstract
Impaired neural control of arteries is implicated in the etiology of diabetes related complications such as diabetic foot. While there is evidence that diabetes impairs neurovascular transmission in animals, there are no reports that sympathetic axons are lost. Here we investigated the effects of streptozotocin (STZ)-induced type I diabetes on rat plantar metatarsal arteries (PMAs). Rats treated with STZ (60mg/kg, i.p.) received 1unit/day (n=6) or 4units/day (n=7) of insulin. Rats treated with a low-dose of insulin had elevated blood glucose levels (>25mM) whereas those treated with a high-dose maintained blood glucose levels <15mM.
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