Abstract
Introduction: Maintenance of a peritoneal membrane is essential for maintaining long-term peritoneal dialysis (PD). Peritoneal protein loss (PPL) is basically the loss of an essential nutrient, which may lead to malnutrition. We aimed to evaluate the association between PPL and sarcopenia in PD patients.Methods: We conducted a cross-sectional study from September 2017 to November 2020 on all PD patients (n = 199). Finally, the patients were divided into tertiles based on the PPL level as follows: low, middle, and high. PPL (mg/day), appendicular lean mass (ALM) using dual-energy X-ray absorptiometry, and handgrip strength (HGS) were evaluated. Sarcopenia was defined using cut-off values from the Asian Working Group for Sarcopenia.Results: The median PPL (interquartile range, interval) in the low, middle, and high tertiles were 4,229 (904, 1,706–5,111), 6,160 (760, 5,118–7,119), and 8,543 (2,284, 7,145–24,406) mg/day, respectively. HGS in the low, middle, and high tertiles was 23.4 ± 9.2, 23.8 ± 8.9, and 23.6 ± 8.3 kg, respectively (P = 0.967). The ALM index in the low, middle, and high tertiles was 6.0 ± 1.3, 6.0 ± 1.2, and 6.5 ± 1.1 kg/m2, respectively (P = 0.061). Multivariate analyses did not reveal significant differences in HGS and ALM index in among tertiles. The proportions of patients with sarcopenia in the low, middle, and high tertiles was 24 (36.4%), 19 (28.4%), and 21 (31.8%), respectively (P = 0.612).Conclusion: The present study showed that PPL is not independently associated with muscle mass, strength, and sarcopenia in PD patients.
Highlights
Maintenance of a peritoneal membrane is essential for maintaining long-term peritoneal dialysis (PD)
We aimed to evaluate the association between Peritoneal protein loss (PPL) and sarcopenia in PD patients
The present study showed that PPL is not independently associated with muscle mass, strength, and sarcopenia in PD patients
Summary
Maintenance of a peritoneal membrane is essential for maintaining long-term peritoneal dialysis (PD). Peritoneal protein loss (PPL) is basically the loss of an essential nutrient, which may lead to malnutrition. Peritoneal dialysis (PD) is a modality among renal replacement therapies, and the proportion of end-stage renal disease (ESRD) patients who underwent PD was 4.1% in Korea and 7.5% in U.S.A [1, 2]. PD involves removal of uremic molecules and/or water through the peritoneal membrane. Proper characteristics and maintenance of a peritoneal membrane are essential for maintaining long-term PD. Maintenance of homeostasis for survival in ESRD patients requires proper function and combination of these pores or transporters. A large pore is associated with removal of large sized uremic toxins (middle molecules) and nutrients (albumin)
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