Abstract
IntroductionMalignant peritoneal mesothelioma is a rare cancer with poor patient survival. Female gender has been identified as a positive prognostic factor. Recently, it has been suggested that the expression of estrogen receptor β in malignant mesothelioma leads to tumor suppression and a better prognosis.Case presentationWe report the case of a 48-year-old Caucasian woman who is alive and disease-free seven years after the initial diagnosis and treatment of malignant peritoneal mesothelioma.ConclusionThis patient's long survival may be attributable to a combination of factors, including minimal disease, complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy plus the estrogen receptor β positivity of the tumor.
Highlights
Malignant peritoneal mesothelioma is a rare cancer with poor patient survival
A number of therapeutic regimens have been used to improve prognosis [5], and currently debulking surgery is followed by hyperthermic intraperitoneal chemotherapy (HIPEC)
No evidence of mesothelioma was found at this stage, and two months later, laparotomy was repeated for division of adhesions and debridement of a large abscess owing to infection
Summary
Peritoneal mesothelioma is a rare but fatal disease; the incidence is approximately one per million, and peritoneal mesothelioma accounts for about 20% to 30% of all cases of mesothelioma [1]. A number of therapeutic regimens have been used to improve prognosis [5], and currently debulking surgery is followed by hyperthermic intraperitoneal chemotherapy (HIPEC). This has led to marked improvement in patients who were once classified as preterminal [6]. Case presentation A Caucasian women, aged 48 years, presented herself at the age of 40 years with abdominal pain Tumor markers such as CA125 appeared to be normal and ranged from 7 to 11, which fell within the reference range (0-35 IU/mL). Macroscopic examination showed occasional atypical cells with minor peritoneal disease (epitheloid cells) consistent with mesothelioma. It was concluded that very low-volume disease was present, and pain was mainly attributable to adhesions
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