Abstract
Periprostatic adipose tissue is a new topic being investigated to determine its utility in detecting and scoring prostate cancer. In the past, most of the studies related to prostate cancer relied on body mass index (BMI) to measure adiposity but showed conflicting results. In recently published clinical trials, periprostatic adipose tissue has been considered as a risk factor for the development of prostate cancer. These studies shifted the focus of researchers from BMI to periprostatic adipose tissue quantification demonstrating its relation with prostate cancer. Similarly, the study of paracrine effects of organ- associated adipose tissue and its association with cancer has also been the major focus for researchers lately. Adipokines have been linked with numerous carcinogenic mechanisms, such as angiogenesis, cell proliferation, metastasis, and alterations in sex-steroid hormone levels. This article basically reviews the clinical studies which used different imaging modalities to quantify periprostatic adipose tissue and its association with prostate cancer. Also, it further explores the specific roles of several adipokines like leptin, interleukin-6 (IL-6) and vascular endothelial growth factor (VEGF) and their mechanism in progression of prostate cancer.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
