Abstract
BackgroundTsukamurella pulmonis is an aerobic gram-positive and rod-shaped organism that causes central catheter-related bloodstream infections in immunocompromised hosts. However, peripherally inserted central catheter (PICC)-related bloodstream infections due to this organism have not been reported.Case presentationWe describe a case of a 48-year-old man with acquired immunodeficiency syndrome and diffuse large B cell lymphoma who received five courses of chemotherapy including rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine, and prednisone via a PICC. Five days after the last chemotherapy course, he presented with a high fever and shaking chills. His absolute neutrophil count was 4200/μL. Cultures obtained from blood and PICC culture revealed T. pulmonis. The colony count of T. pulmonis grown from PICC culture was 103 colony-forming units. Therefore, he was diagnosed with T. pulmonis bacteremia resulting from PICC-related bloodstream infection. The patient’s condition improved and he became afebrile within 48 h after intravenous administration of cefozopran hydrochloride, which is a fourth generation cephalosporin.ConclusionsPICCs can be associated with T. pulmonis bacteremia, and fourth generation cephalosporins may be effective treatment.
Highlights
Tsukamurella pulmonis is an aerobic gram-positive and rod-shaped organism that causes central catheter-related bloodstream infections in immunocompromised hosts
Peripherally inserted central catheters (PICCs) can be associated with T. pulmonis bacteremia, and fourth generation cephalosporins may be effective treatment
We present the case of 48-year-old patient with acquired immunodeficiency syndrome (AIDS) who was diagnosed with PICC-related bloodstream infection due to T. pulmonis
Summary
PICCs can be associated with T. pulmonis bacteremia, and fourth generation cephalosporins may be effective treatment.
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