Abstract
BackgroundThe purpose of this study was to identify the clinical characteristics and outcomes of peripheral vascular catheter-related bloodstream infections (PVC-BSIs) and determine the risk of severe complications or death.MethodsWe performed a retrospective observational study from June 2010 to April 2015 at two regional university-affiliated hospitals in Tokyo. We studied the clinical manifestations, underlying diseases, laboratory results, treatment methods, recurrence rates, and complications in 62 hospitalized patients diagnosed with PVC-BSIs by positive blood cultures.ResultsThe median time from admission to bacteremia was 17 days (range, 3–142 days) and that from catheter insertion to bacteremia diagnosis was 6 days (range, 2–15 days). Catheter insertion sites were in the arm in 48 (77.4%) patients, in the foot in 3 (4.8%) patients, and in an unrecorded location in 11 (17.7%) patients. Additionally, the causative pathogens were Gram-positive microorganisms in 58.0% of cases, Gram-negative microorganisms in 35.8% of cases, Candida spp. in 6.2% of cases, and polymicrobials in 25.8% of cases. Eight (12.9%) patients died within 30 days of their blood culture becoming positive. Patients who died of PVC-BSIs had a higher proportion of Staphylococcus aureus infection than patients who survived (odds ratio, 8.33; p = 0.004).ConclusionsPVC-BSIs are a significant cause of health care-associated infection. We observed cases of severe PVC-BSI requiring intensive and long-term care along with lengthy durations of antibiotic treatment due to hematogenous complications, and some patients died. For patients with PVC-BSIs, S. aureus bacteremia remains a major problem that may influence the prognosis.
Highlights
The purpose of this study was to identify the clinical characteristics and outcomes of peripheral vascular catheter-related bloodstream infections (PVC-BSIs) and determine the risk of severe complications or death
The catheter retained in a blood vessel is the most common cause of bloodstream infections, and catheter-related bloodstream infection (CRBSI) has been the subject of
We retrospectively studied the clinical manifestations, underlying diseases, laboratory results, treatment methods, recurrence rates, and complications in 62 patients diagnosed with PVC-BSIs by positive blood cultures from 1 June 2010 to 30 April 2015 at two regional hospitals in Tokyo: Tokyo Medical University Hospital (a 1015-bed university-affiliated hospital) and Tokyo Medical University Hachioji Medical Center (a 610-bed university-affiliated hospital)
Summary
The purpose of this study was to identify the clinical characteristics and outcomes of peripheral vascular catheter-related bloodstream infections (PVC-BSIs) and determine the risk of severe complications or death. We sometimes observe PVC-BSI cases that subsequently cause local and systemic complications, suppurative thrombophlebitis, and osteomyelitis. These complications may become severe, necessitating admission to the intensive care unit and resulting in death in some cases. Severe infection is much less frequent (0.036–0.100% of cases) but is responsible for high morbidity and mortality rates [11] These severe complications lengthen the treatment period and worsen the prognosis. Recognize that in addition to CVC-BSIs, PVC-BSIs are important nosocomial infections
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