Abstract
Pyoderma gangrenosum is an unusual necrotizing noninfective and ulcerative skin disease whose cause is unknown. Ophthalmic involvement in pyoderma gangrenosum is an unusual event. Only a few cases have been reported, from which we can highlight scleral, corneal, and orbital cases. Peripheral ulcerative keratitis is a process which destroys the peripheral cornea. Its cause is still unknown although it is often associated with autoimmune conditions. Pyoderma gangrenosum should be included in the differential diagnosis of peripheral ulcerative keratitis. Early recognition of these manifestations can vary the prognosis by applying the appropriate treatment. We introduce a 70-year-old woman who suffered pyoderma gangrenosum associated with peripheral ulcerative keratitis in her left eye. The patient's skin lesions and peripheral keratitis responded successfully to systemic steroids and cyclosporine A.
Highlights
Pyoderma gangrenosum (PG) is an unusual necrotizing noninfective and ulcerative skin disease of unknown cause that has been included among the so-called neutrophilic dermatoses
We report a case of PG associated with peripheral ulcerative keratitis (PUK) in a 70-yearold woman
PG may appear in healthy patients or in those associated with a variety of systemic diseases
Summary
Pyoderma gangrenosum (PG) is an unusual necrotizing noninfective and ulcerative skin disease of unknown cause that has been included among the so-called neutrophilic dermatoses. The condition is clinically characterized by necrotic and deep ulcers that are previously preceded by inflammatory pustules [1, 2]. Under the term peripheral ulcerative keratitis (PUK), a group of inflammatory corneal diseases clinically characterized by peripherical corneal thinning, cellular infiltration, ulceration, and variable degree vasoocclusion and injection of the adjacent vascular network are included [3, 4]. A few cases have been reported, from which we can highlight scleral, corneal, and orbital cases [5,6,7,8,9,10]. We report a case of PG associated with PUK in a 70-yearold woman. The patient’s skin lesions and peripheral keratitis responded successfully to systemic steroids and cyclosporine A
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