Abstract
Non-freezing cold injury (NFCI) is caused by prolonged exposure of the extremities to cold. The long-term sequelae of NFCI, include cold-sensitivity and pain[1]. The cold sensitivity is characterised by a reduction in basal skin blood flow and augmented vasoconstriction during cold exposure. We tested the hypothesis that sublingual GTN would increase blood flow in the peripheral microcirculation during and after a mild cold challenge in individuals who had not been diagnosed with NFCI, but were cold-sensitive.
Highlights
Non-freezing cold injury (NFCI) is caused by prolonged exposure of the extremities to cold
The cold sensitivity is characterised by a reduction in basal skin blood flow and augmented vasoconstriction during cold exposure
We tested the hypothesis that sublingual Glyceryl Trinitrate (GTN) would increase blood flow in the peripheral microcirculation during and after a mild cold challenge in individuals who had not been diagnosed with NFCI, but were cold-sensitive
Summary
Non-freezing cold injury (NFCI) is caused by prolonged exposure of the extremities to cold. The long-term sequelae of NFCI, include cold-sensitivity and pain[1]. The cold sensitivity is characterised by a reduction in basal skin blood flow and augmented vasoconstriction during cold exposure. We tested the hypothesis that sublingual GTN would increase blood flow in the peripheral microcirculation during and after a mild cold challenge in individuals who had not been diagnosed with NFCI, but were cold-sensitive
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