Peripheral regional aseptic neutrophilic lymphadenopathy associated with pyoderma gangrenosum

Abstract

E‐mail: firas55@hotmail.com Conflicts of interest: none declared. Sir, Neutrophilic dermatoses (NDs) are a group of disorders characterized by sterile, neutrophilic cutaneous infiltrates with or without the presence of systemic symptoms. The term encompasses Sweet syndrome (SS), pyoderma gangrenosum (PG), subcorneal pustular dermatosis (SCPD), erythema elevatum diutinum, ND of the dorsal hands and others.1, 2 Underlying internal disorders, as described here, are frequently associated with PG and with other NDs.3 PG is an uncommon disorder of the skin characterized by a rapid onset of painful ulceration with a purple‐coloured border and a mucopurulent necrotic base. It may occur in isolation but is often associated with inflammatory bowel disease (IBD), rheumatoid arthritis or haematological disorders.4, 5 Peristomal PG is particularly associated with IBD. Extracutaneous manifestations affecting the lung, joints, bowels, kidneys, eyes, heart, liver and spleen have been described with NDs, but predominate in SS.3, 6 These manifestations are separate from the internal features of the associated underlying disorder. Internal lymphadenopathy related to NDs has been reported in SCPD.7 We report a case of peripheral lymphadenopathy associated with PG in a patient with underlying ulcerative colitis (UC).