Abstract
ABSTRACT The effect of dexamethasone1) on the peripheral plasma levels of the sex steroids was investigated in four pregnant monkeys during six treatments at the end of the second and third trimesters. A daily dose of 10 mg dexamethasone was administered intramuscularly into each pregnant monkey for three days. All the treated monkeys delivered normal healthy babies within the expected time of parturition. A decrease in oestrogens and an increase in progesterone in the peripheral blood plasma were observed during the dexamethasone treatment. The increase in the peripheral plasma levels of progesterone observed was greater in the monkeys treated at the end of the second trimester. The peripheral plasma levels of 17α-hydroxyprogesterone were very low and showed no change in any of the pregnant monkeys treated with dexamethasone.
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