Abstract
Peripheral odontogenic fibroma (POF), a rare benign neoplasm of odontogenic ectomesenchymal origin, represents approximately 4.7% of all odontogenic tumors. A 29-year-old white woman was referred for evaluation of a painless, slow-growing swelling in the gingiva, identified 2 years earlier. Her medical history was unremarkable. Intraoral examination showed a reddish, soft nodule, measuring approximately 1.5 × 0.8 cm, in the right vestibular mandibular gingiva between the second premolar and the first molar. Radiographic examination revealed small crestal bone loss in the region. In view of a provisional diagnosis of pyogenic granuloma or peripheral giant cell lesion, excisional biopsy was performed. Histopathologic analysis confirmed a tumor composed of cellular, fibroblastic connective tissue intermixed with abundant islands and strands of apparently inactive odontogenic epithelium. The final diagnosis was epithelium-rich POF. Nine months after surgical excision, clinical signs of recurrence were not detected. The patient remains under clinical follow-up.
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