Abstract
Peripheral neuropathy in alcoholics is usually attributed to a lack of aneurin (Victor and Adams, 1961) ; however, it is often not possible to document this relation by diagnostic or thera peutic tests. Demonstration that pantothenic acid (Hodges et al., 1958) or pyridoxine (Biehl and Vilter, 1954) deficiency may cause peripheral nerve dysfunction suggests that lack of these or other B-complex vitamins may also contribute to neuropathy in the malnourished alcoholic. The present investi gation was therefore undertaken to evaluate further the role of aneurin and other B-complex vitamins in the development of this condition. The study consisted of (a) determining circu lating levels of aneurin, riboflavin, nicotinic acid, pantothenic acid, biotin, pyridoxine, vitamin B12, and folie acid in alcoholic patients with and without neuropathy ; and (b) an evaluation of the responsiveness of patients with neuropathy to various members of the B-complex group.
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