Abstract
Background: To estimate the prevalence and risk factors of peripheral neuropathy (PN) in people with type 2 diabetesmellitus. Methods: 810 patients with type 2 diabetes (289 male and 521 female) from Isfahan Endocrinology and MetabolismResearch Centre outpatient clinics, Iran , were examined. Part of the examination included an assessment of neurologicalfunction including neuropathic symptoms and physical signs, and nerve conduction velocity. Results: The prevalence of PNwas 75.1% (95% confidence interval (CI) 72.1, 78.0). Peripheral neuropathy was associated with age, proteinuria, andduration of diabetes, insulin-treatment, and presence of retinopathy and ischaemic heart disease (IHD). The age-adjustedprevalence rate of PN was 78% higher among patients with IHD, 64% higher among patients with any retinopathy, 66%higher among insulin-treated type 2 diabetes, and greater with duration of diabetes. Using a stepwise binary logisticregression model, age, duration of diabetes and proteinuria were significant independent predictors of PN. Conclusion: PN isa common complication in this population of Iranian type 2 diabetic patients. It increases with age, duration of diabetes andproteinuria. (Int J Diabetes Metab 14: 126-133, 2006)
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