Abstract
AbstractPurpose To analyse corneal nerve morphology alterations in patients with chronic renal failure by in vivo corneal confocal microscopy (CCM).Methods A prospective study was conducted in 30 patients (30 eyes) with pre‐dialysis chronic renal failure (CRF) and 30 aged‐matched healthy volunteers (30 eyes). A complete ophthalmologic examination, esthesiometry (Cochet‐Bonnet esthesiometer), in vivo CCM (Heidelberg Retina Tomograph II/Rostock Cornea Module) and neurological evaluation were performed.Results Corneal sensation was reduced in pre‐dialysis CRF patients compared with control subjects. Nerve fiber density, length and branch density were reduced and tortuosity was increased in the CRF group (p<0,05). These parameters were related with severity of neuropathy.Conclusion In vivo CCM may be a valuable method for diagnosis of uremic neuropathy and may be used to grade its severity.
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