Abstract
The search for new effective methods to prevent or mitigate ischemic myocardial damage and the mechanisms for their realization is an important task of modern experimental and clinical medicine. The aim of the study was to elucidate the significance of peripheral M-choline-reactive systems in the realization of the cardioprotective effects of remote ischemic postconditioning (RIPostC) during ischemia-reperfusion of myocardium in experiment. The study revealed that RIPostC has an infarct-limiting effect during ischemia-reperfusion of myocardium in young and old rats, but under the conditions of systemic action of atropine (2 mg/kg), the infarct-limiting effect of RIPostC remained only in old rats. It seems that the activity of peripheral M-choline-reactive systems is important in the mechanisms of realization of the cardioprotective effects of RIPost in young, but not in old rats.
Highlights
The search for new effective methods to prevent or mitigate ischemic myocardial damage and the mechanisms for their realization is an important task of modern experimental and clinical medicine
В клинической практике необходимость защиты миокарда от ишемического и реперфузионного повреждения чаще всего возникает у пациентов с различными факторами риска сердечно-сосудистых заболеваний, к числу которых относится и возраст
В ходе исследования также установлено, что у старых крыс во время острой ишемии миокарда в группе Контрольстар у 4 из 7 крыс отмечалась ФЖ, а у 6 животных данной группы была выявлена ПЖТ
Summary
The search for new effective methods to prevent or mitigate ischemic myocardial damage and the mechanisms for their realization is an important task of modern experimental and clinical medicine. Изучение кардиопротекторной эффективности ДИПостК при ишемии и реперфузии миокарда у старых и молодых крыс в условиях блокады М-холинореактивных систем проводилось у животных, которым за 10 мин до воспроизведения ДИПостК внутривенно вводили в левую общую яремную вену 0,2 %-ный раствор М-холиноблокатора атропина (Sigma, США) в дозе 2 мг/кг.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Proceedings of the National Academy of Sciences of Belarus, Medical series
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
