Abstract
Systemic inflammation is correlated with dementia progression. Pro-inflammatory molecules can communicate from the periphery to the central nervous system to induce neuroinflammation and neurodegeneration. Our protein of interest is the pro-apoptotic kinase PKR (the double strand-RNA dependent protein kinase). Increased activated PKR levels were found in AD patients brain and cerebrospinal fluid. PKR activation can be triggered by inflammatory stresses and induces neurotoxicity in vitro. Is in vivo PKR-mediated inflammation involved in AD neurodegenerative process?
Highlights
Systemic inflammation is correlated with dementia progression
PKR activation can be triggered by inflammatory stresses and induces neurotoxicity in vitro
Is in vivo PKR-mediated inflammation involved in AD neurodegenerative process?
Summary
Peripheral inflammation increases PKR activation, Tau phosphorylation and amyloid b production in wild-type mice. François Mouton-Liger1,2*, Anne-Sophie Rebillat, Clarisse Pace, Sarah Gourmaud, Mariko Taga, Claire Paquet, Jacques Hugon. From Molecular Neurodegeneration: Basic biology and disease pathways Cannes, France. From Molecular Neurodegeneration: Basic biology and disease pathways Cannes, France. 10-12 September 2013
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
