PERIPHERAL GIANT CELL LESION ASSOCIATED WITH PERIPHERAL OSSIFYING FIBROMA: A RARE CASE REPORT

Abstract

Lesions formed by the combination of microscopic aspects of peripheral giant cell lesion (PGCL) and peripheral ossifying fibroma (POF) are rare. Whether they represent true hybrid lesions or part of a disease spectrum is debatable. A 38-year-old woman was referred for evaluation of a painless, slow-growing swelling on the mandible that had been identified 6 months earlier. Intraoral examination revealed a pinkish nodule with whitish, erythematous, and ulcerated areas located on the buccal gingiva of teeth #37 and #38. Computed tomography revealed hyperdense foci in the lesion and erosion of the underlying bone cortex. Under the diagnostic hypothesis of POF, an excisional biopsy was performed. Histopathologic analysis revealed proliferation of oval to spindle-shaped mononucleated mesenchymal cells, interspersed with multinucleated giant cells. Extensive deposition of trabecular bone intermixed by cellular fibroblastic tissue could also be observed. The definitive diagnosis was PGCL associated with POF. The patient remains under close follow-up. Lesions formed by the combination of microscopic aspects of peripheral giant cell lesion (PGCL) and peripheral ossifying fibroma (POF) are rare. Whether they represent true hybrid lesions or part of a disease spectrum is debatable. A 38-year-old woman was referred for evaluation of a painless, slow-growing swelling on the mandible that had been identified 6 months earlier. Intraoral examination revealed a pinkish nodule with whitish, erythematous, and ulcerated areas located on the buccal gingiva of teeth #37 and #38. Computed tomography revealed hyperdense foci in the lesion and erosion of the underlying bone cortex. Under the diagnostic hypothesis of POF, an excisional biopsy was performed. Histopathologic analysis revealed proliferation of oval to spindle-shaped mononucleated mesenchymal cells, interspersed with multinucleated giant cells. Extensive deposition of trabecular bone intermixed by cellular fibroblastic tissue could also be observed. The definitive diagnosis was PGCL associated with POF. The patient remains under close follow-up.