Abstract
Material and Methods 18 patients with allergic asthma (AA) and 14 patients with allergic rhinitis (AR) were examined. The control group included 16 healthy subjects (HS). All AA and AR patients did not take inhaled corticosteroids at least for one month and/or histamine antagonists at least for one week. Peripheral blood eosinophils and CD4+ cells were isolated by high density gradient centrifugation and magnetic separation. Th9 cells and apoptotic eosinophils were estimated by flow cytometer. Serum interleukin-9 (IL-9) and interleukin-5 (IL-5) level was determined by ELISA.
Highlights
Th9 cells are novel identified subset of CD4+ T helper cells, which could contribute to airway inflammation in allergic asthma
Airway inflammation in allergic asthma was accompanied by increased peripheral blood Th9 cell count and IL-9 level
Eosinophil apoptosis was inversely related to serum IL-9 level
Summary
Th9 cells are novel identified subset of CD4+ T helper cells, which could contribute to airway inflammation in allergic asthma. The role of Th9 cells and their interaction with eosinophils is still not fully understood. The aim was to evaluate peripheral blood Th9 cells and eosinophil apoptosis in patients with allergic asthma
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