Abstract
Purpose PFAPA is an autoinflammatory syndrome of childhood characterized by recurrent attacks of fever, aphthous stomatitis, pharyngitis and adenitis. The underlying immune disorder is poorly understood, albeit activation of Th1 related cytokines has been observed. We aimed to compare concentration of proinflammatory cytokines and selected chemokines in PB during and between febrile episodes in children with PFAPA.
Highlights
Peripheral blood (PB) concentrations of neutrophil chemoattractant IL-8 and Th1-related cytokines are elevated during febrile episodes in children with periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome
PFAPA is an autoinflammatory syndrome of childhood characterized by recurrent attacks of fever, aphthous stomatitis, pharyngitis and adenitis
Concentration of GM-CSF, INFg, IL-1b, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10 and TNFa were simultaneously measured in PB using the multiplex ELISA technique
Summary
Peripheral blood (PB) concentrations of neutrophil chemoattractant IL-8 and Th1-related cytokines are elevated during febrile episodes in children with periodic fever, aphthous stomatitis, pharyngitis and adenitis (PFAPA) syndrome. From 2011 Pediatric Rheumatology Symposium sponsored by the American College of Rheumatology Miami, FL, USA. Purpose PFAPA is an autoinflammatory syndrome of childhood characterized by recurrent attacks of fever, aphthous stomatitis, pharyngitis and adenitis. The underlying immune disorder is poorly understood, albeit activation of Th1 related cytokines has been observed.
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