Abstract
Aims: 1. To evaluate the prognostic value of SpO2 in cancer patients 2. To correlate between daily SpO2 values and tumor response to radiation. Background: Tumor hypoxia is an important prognostic factor in Oncology. It plays an important role in tumorogenesis, radiation resistance and tumor progression. Many invasive and in-vitro methods are available to assess the hypo-oxygenated status of tumors. Objective: We evaluated if SpO2 values measured from pulse oximetry could be used as an adjunct prognostic and predictive factor in oncology patients. Methods: Ten consecutive patients with locally advanced, non-metastatic disease were evaluated. Daily SpO2 measurements throughout the treatment and weekly haemoglobin values were noted. All patients received radical intent radiation therapy. Patients were categorised into two groups: poor SpO2 (<97mmHg) and better SpO2 (≥98mmHg). Results: Tumour response was higher in patients with better SpO2 (≥98mmHg). Patients with poor SpO2 (<97mmHg) presented with bulkier disease at diagnosis. Conclusion: Role of SpO2 as a prognostic and predictive factor should be explored further with in vitro and pH studies.
Highlights
Prognostic and predictive factors have been the Holy Grail of Oncology
We evaluated if SpO2 values measured from pulse oximetry could be used as an adjunct prognostic and predictive factor in oncology patients
[4] In this study, we reported the use of SpO2 values from Pulse oximetry as a non-invasive prognostic factor in patients with
Summary
Prognostic and predictive factors have been the Holy Grail of Oncology. Oxygen has been long since known to play a critical role in the response of tumour to radiation and has been proven to be a prognostic factor clinically [3].Many of the methods used to determine the oxygen saturation of cancerous tumours include the use of invasive techniques such as probes and assays [4] In this study, we reported the use of SpO2 values from Pulse oximetry as a non-invasive prognostic factor in patients with. David and Lokesh locally advanced disease and as a predictive factor for response to radiation therapy. Tumor hypoxia is an important prognostic factor in Oncology. It plays an important role in tumorogenesis, radiation resistance and tumor progression. Many invasive and in-vitro methods are available to assess the hypo-oxygenated status of tumors
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