Abstract
Purpose: Knee osteoarthritis (OA) is a heterogeneous disease characterized by a variety of clinical and molecular phenotypes, and has been described as a chronic systemic inflammatory disease. Substantial epigenetic changes have been identified in OA joints, but less is known about extraarticular tissues. In this study, we apply tensor composition analysis to extract cell-type-specific DNA methylation data from baseline buffy coat DNA samples in a subgroup of osteoarthritis initiative (OAI) patients who exhibited future pain, radiographic, or pain+radiographic progression compared to nonprogressor controls.
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