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Abstract
Objective: The aim of the present study was to analyze if alterations of peripheral-type benzodiazepine receptor (PBR) characteristics occurred in platelet membranes of patients affected by primary fibromyalgia (FM). Design and methods: Platelets were obtained from 30 patients with FM. Evaluation of kinetic parameters of PBR was performed using [ 3H] PK11195 as specific radioligand compared with 16 healthy volunteers. Results: The results showed a significant increase of PBR binding sites value in platelet membranes from FM patients ( B max was 5366 ± 188 fmol/mg vs. controls, 4193 ± 341 fmol/mg, mean ± SEM) (** p < 0.01) but not for affinity value ( K d was 4.90 ± 0.39 nM vs. controls, 4.74 ± 0.39 nM, mean ± SEM) ( p > 0.05). Symptom severity scores (pain and tiredness) were positively correlated with B max. Conclusions: Our results showed an up-regulation of PBR in platelets of FM patients, and this seems to be related to the severity of fibromyalgic symptoms.
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