Abstract
This study aimed to quantify the different effect of external cuff pressure on arterial volume distensibility between peripheral arteries with different compliance. 30 healthy subjects were studied with the arm at two positions (0° and 45° from the horizontal level) to introduce different compliance of arteries. The electrocardiogram and finger and ear photoplethysmograms were recorded simultaneously under five external cuff pressures (0, 10, 20, 30 and 40 mmHg) on the whole arm to obtain arterial volume distensibility. With the applied external cuff pressures of 10, 20, 30 and 40 mmHg, the overall changes in arterial volume distensibility referred to those without external pressure were 0.010, 0.029, 0.054 and 0.108% per mmHg for the arm at the horizontal level, and 0.026, 0.071, 0.170 and 0.389% per mmHg for the arm at 45° from the horizontal level, confirming the non-linearity between arterial volume distensibility and external pressure. More interestingly, the significant differences in arterial volume distensibility changes were observed between the two arm positions, which were 0.016, 0.043, 0.116 and 0.281% per mmHg (all P < 0.01). Our findings demonstrated that arterial volume distensibility of peripheral arm arteries increased with external pressure, with a greater effect for more compliant arteries.
Highlights
The definition of arterial volume distensibility clearly shows that transmural pressure is one of the most sensitive factors causing the changes of arterial properties
With a long air-filled pressure cuff and by positioning the arm above the horizontal level, the measurement of peripheral arterial volume distensibility using arm propagation time has been performed over a range of low transmural pressures
By positioning the arm at the two different positions (0° and 45° from the horizontal level), when there was no external pressure applied on the arm arteries, the arterial volume distensibility were 0.105% and 0.176% per mmHg, respectively
Summary
The definition of arterial volume distensibility clearly shows that transmural pressure is one of the most sensitive factors causing the changes of arterial properties. The non-linearity between arterial volume distensibility and blood pressure (BP) has been widely reported[14,15,16]. Our previous study quantified the inverse and non-linear relationship between arterial volume distensibility and arterial pressure using a simple arm positioning procedure[11]. The non-linearity between arterial volume distensibility and external pressure has been experimentally studied by Zheng and Murray[12]. To the best of our knowledge, there have been no similar experimental studies designed to examine the different effect of external pressure on arterial volume distensibility between peripheral arteries with different compliance or distensibility. With the same external pressure applied on the peripheral arm artery, more compliant the artery is, the bigger change in arterial volume distensibility would be measured
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