Abstract
Two patients with hypertension and hyperdynamic beta-adrenergic circulatory state were treated with the beta-adrenergic blocking drug, propranolol hydrochloride. Hypertension and symptoms remitted, but remission was associated with evidence of peripheral arterial insufficiency. When propranolol therapy was discontinued, arterial insufficiency disappeared. These findings suggest that beta-adrenergic blocking drugs should be used cautiously in patients with peripheral arterial insufficiency and when arterial insufficiency appears with such treatment, beta-adrenergic inhibition should be considered the cause.
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