Peripheral Arterial Disease in Type 2 Diabetes Is Associated with an Increase in Fibrinogen Levels.

Qin-Fen Chen,Hui-Hui Deng,Hong Zhu,Dan Cao,Ting-Ting Ye

doi:10.1155/2018/3709534

Abstract

Background The present study is undertaken to investigate the fibrinogen levels in type 2 diabetes mellitus (T2DM) and its relation to peripheral artery disease (PAD) based on a more accurate and applied noninvasive measurements of duplex ultrasonography. Methods We performed a cross-sectional study including 1096 T2DM patients (474 males and 622 females). The odds ratios (ORs) and 95% confidence intervals (CIs) were presented to show the association between PAD and fibrinogen in the subjects divided by fibrinogen levels quarterly. Furthermore, the univariate and multiple logistic analyses were performed to explore the correlation between PAD and fibrinogen levels, individual components in the cross-sectional study. Results Finally, 887 (80.9%) T2DM patients meet the diagnostic criteria of PAD and these patients had considerably higher serum fibrinogen concentration than non-PAD group (P < 0.001). Multiple logistic analyses revealed that higher fibrinogen quartiles were positively related with the development of PAD in the adjusted model. After adjusting for known confounding parameters, the ORs for PAD were 1.993 (95% CI: 1.322-3.005, P < 0.001), 2.469 (95% CI: 1.591-3.831, P < 0.001), and 2.942 (95% CI, 1.838-4.711, P < 0.001) for Q2, Q3, and Q4, respectively (all P values <0.05). Conclusions Our results suggest that serum fibrinogen concentration can be considered as an independent risk factor for PAD in T2DM patients.

Highlights

Type 2 diabetes mellitus (T2DM) enhances the risk of lower extremity peripheral artery disease (PAD) and hemostatic and inflammatory disturbances with serious consequences on morbidity and mortality [1]
Patients with PAD were determined with an ankle brachial index (ABI) in the previous reports, the medial arterial calcification occurs in some patients suffering from diabetes, which results in an inadequate increase of the assessed ABI and inhibits accurate determination of the ABI
In order to analyze the relationship of PAD and fibrinogen, the study population was divided into quarters according to the fibrinogen concentration (Q1: ≤3.01 g/L; Q2: 3.02-3.65 g/L; Q3: 3.664.55 g/L; and Q4: ≥4.56 g/L)

Summary

Introduction

Type 2 diabetes mellitus (T2DM) enhances the risk of lower extremity peripheral artery disease (PAD) and hemostatic and inflammatory disturbances with serious consequences on morbidity and mortality [1]. Patients with PAD were determined with an ankle brachial index (ABI) in the previous reports, the medial arterial calcification occurs in some patients suffering from diabetes, which results in an inadequate increase of the assessed ABI and inhibits accurate determination of the ABI. The present study is undertaken to investigate the fibrinogen levels in type 2 diabetes mellitus (T2DM) and its relation to peripheral artery disease (PAD) based on a more accurate and applied noninvasive measurements of duplex ultrasonography. Our results suggest that serum fibrinogen concentration can be considered as an independent risk factor for PAD in T2DM patients

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