Abstract
The differentiation between central and peripheral analgesic drugs is nowadays of more or less historical value. Most of the so-called peripheral analgesics possess anti-inflammatory properties and in some cases also antipyretic activity besides analgesia. For many of them, the mode of action has been elucidated as an inhibition of cyclooxygenase in the prostaglandin pathway. Nevertheless, new peripheral analgesics have to be tested not only for their in vitro activity on cyclooxygenase but also for their in vivo activity. The most commonly used methods for measuring peripheral analgesic activity are the writhing tests in mice (various modifications) and the Randall–Selitto test in rats.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
