Abstract
Although primary open-angle glaucoma (OAG) generally occurs in older individuals and manifests in eyes with elevated intraocular pressure (IOP), it may also occur in young patients or in eyes with an IOP that always measures within the statistically normal range. Recent advances in optical coherence tomography angiography have enabled noninvasive visualization of the vasculature around the optic disc. In this study, we investigated the clinical features of young Korean patients with OAG and compared the peripapillary vessel density of patients with normal-tension glaucoma (NTG) to those with high-tension glaucoma (HTG). The peripapillary vessel density was reduced in eyes with HTG compared with that in normal subjects (HTG: 23.18 ± 2.06% vs. normal subjects: 24.74 ± 1.88%, P value = 0.013). In contrast, the peripapillary vessel density of eyes with NTG was comparable with that of normal eyes (NTG: 23.98 ± 2.30% vs. normal subjects: 24.74 ± 1.88%, P value = 0.505). These findings suggest that young patients with HTG show greater peripapillary microvascular attenuation than healthy subjects or young patients with NTG, indicating that different levels of the initial untreated IOP may have different effects on the peripapillary vessel density in young patients with OAG.
Highlights
In young adults with glaucomatous optic disc and normal intraocular pressure (IOP) and age- and sex-matched normal subjects[16]
We evaluated the vessel density around the optic disc using Optical coherence tomography angiography (OCTA) in young patients with open-angle glaucoma (OAG), and compared the peripapillary vessel density and structural features of optic disc between normal-tension glaucoma (NTG) and high-tension glaucoma (HTG) groups
We reviewed the medical records of 201 young patients with OAG, excluding 97 because of the following reasons: previous history of ocular or refractive surgery (37 patients), preperimetric glaucoma (23 patients), secondary glaucoma (18 patients), refractive error
Summary
In young adults with glaucomatous optic disc and normal IOP and age- and sex-matched normal subjects[16]. The retinal arteriolar narrowing was associated with glaucomatous optic disc in young adults, independent of an increase in IOP. These studies suggested that the reduced ocular blood flow from a narrow central retinal arteriole in young patients with NTG might induce glaucomatous damage, which supports the vascular theory of the pathogenesis of glaucomatous optic neuropathy. It remains unclear whether such association is a cause or a result of glaucomatous damage. We evaluated the vessel density around the optic disc using OCTA in young patients with OAG, and compared the peripapillary vessel density and structural features of optic disc between NTG and HTG groups
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