Periostin serves an important role in the pathogenesis of oral squamous cell carcinoma.

Yuanyuan Kang,Yan Sun,Ying Zhang,Xue Wang

doi:10.3892/ol.2018.9660

Yuanyuan Kang, Yan Sun + Show 2 more

Open Access

https://doi.org/10.3892/ol.2018.9660

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Abstract

The mechanism underlying OSCC tumorigenesis remains unclear. Periostin is considered to be a prominent oncogene in various solid tumors, although its precise role in OSCC progression remains unknown. In the present study, periostin expression was examined in surgical specimens of OSCC cases, and the results were analyzed for possible correlations with clinical characteristics. In addition, the proliferation and invasiveness of OSCC cells were evaluated following transfection with a Periostin small interfering RNA or an overexpression plasmid. The results revealed that periostin levels were significantly higher in patients with OSCC as compared with those in the controls (P<0.05). In addition, periostin levels in patients with OSCC were significantly associated with permeation classification. Furthermore, periostin expression was observed to promote the proliferation and invasiveness of OSCC cells. The present results suggest that periostin is significantly involved in the pathogenesis of OSCC.

Highlights

Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent cancers and a major cause of mortality in patients with cancer worldwide, and 330,000 mortality cases are reported each year as a result of this disease [1]
The results demonstrated that the knockdown of periostin by siPeriostin significantly suppressed the proliferation of oral squamous cell carcinoma (OSCC) cells, whereas the upregulation of periostin markedly increased the proliferation of OSCC cells (Fig. 2C)
The results revealed that the knockdown of periostin significantly suppressed the invasiveness of OSCC cells, whereas periostin upregulation significantly increased the invasion by OSCC cells (Fig. 3)

Summary

Introduction

Head and neck squamous cell carcinoma (HNSCC) is one of the most prevalent cancers and a major cause of mortality in patients with cancer worldwide, and 330,000 mortality cases are reported each year as a result of this disease [1]. Half of these cases involve oral squamous cell carcinoma (OSCC) [2], which is a highly aggressive head and neck tumor prone to local recurrence and metastasis [3]. The development of OSCC is a long‐term, multistage and multifactorial process, and numerous regulatory factors are involved in its carcinogenesis [4]. Considering the role of periostin in epithelial‐mesenchymal transition (EMT), extracellular matrix (ECM) restructuring and remodeling, research has been focusing on the role of periostin in oncology [8]

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