Year-end Sale % OFF 
Abstract
Matricellular proteins are involved in the crosstalk between cells and their environment and thus play an important role in allergic and inflammatory reactions. Periostin, a matricellular protein, has several documented and multi-faceted roles in health and disease. It is differentially expressed, usually upregulated, in allergic conditions, a variety of inflammatory diseases as well as in cancer and contributes to the development and progression of these diseases. Periostin has also been shown to influence tissue remodelling, fibrosis, regeneration and repair. In allergic reactions periostin is involved in type 2 immunity and can be induced by IL-4 and IL-13 in bronchial cells. A variety of different allergic diseases, among them bronchial asthma and atopic dermatitis (AD), have been shown to be connected to periostin expression. Periostin is commonly expressed in fibroblasts and acts on epithelial cells as well as fibroblasts involving integrin and NF-κB signalling. Also direct signalling between periostin and immune cells has been reported. The deposition of periostin in inflamed, often fibrotic, tissues is further fuelling the inflammatory process. There is increasing evidence that periostin is also expressed by epithelial cells in several of the above-mentioned conditions as well as in cancer. Augmented periostin expression has also been associated with chronic inflammation such as in inflammatory bowel disease (IBD). Periostin can be expressed in a variety of different isoforms, whose functions have not been elucidated yet. This review will discuss potential functions of periostin and its different isoforms in allergy and inflammation.
Highlights
Periostin is a matricellular protein originally isolated from osteoblasts and found to be preferentially expressed in the periosteum [1, 2]
The C-terminal domain shows a high degree of alternative splicing, is known to bind heparin and heparan sulfate proteoglycans (HSPGs) and to modulate the binding mediated by the other domains [7]
Periostin is mainly localised in the extracellular matrix (ECM) and some of its activities are mediated by its binding to cell surface receptors of the integrin family [8]
Summary
Periostin is a matricellular protein originally isolated from osteoblasts and found to be preferentially expressed in the periosteum [1, 2]. RA, Rheumatoid arthritis; AS, Ankylosing Spondylitis; IBD, Inflammatory bowel disease; EGID, Eosinophilic gastrointestinal disorder; EoE, eosinophilic esophagitis; AD, Atopic dermatitis; AC, Allergic conjunctivitis; CRS, Chronic Rhinosinusitis.Additional supporting references [24,25,26,27, 34, 42, 51, 62, 63].
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
