Perioperative Use of Gabapentinoids: Reply.

Abstract

Correspondence| April 2021 Perioperative Use of Gabapentinoids: Reply Michael Verret, M.D., M.Sc. candidate, F.R.C.P.C.; Michael Verret, M.D., M.Sc. candidate, F.R.C.P.C. Search for other works by this author on: This Site PubMed Google Scholar Ryan Zarychanski, M.D., M.Sc., F.R.C.P.C.; Ryan Zarychanski, M.D., M.Sc., F.R.C.P.C. Search for other works by this author on: This Site PubMed Google Scholar François Lauzier, M.D., M.Sc., F.R.C.P.C.; François Lauzier, M.D., M.Sc., F.R.C.P.C. Search for other works by this author on: This Site PubMed Google Scholar Alexis F. Turgeon, M.D., M.Sc., F.R.C.P.C. Alexis F. Turgeon, M.D., M.Sc., F.R.C.P.C. Search for other works by this author on: This Site PubMed Google Scholar Author and Article Information CHU de Québec - Université Laval Research Center and Université Laval, Québec City, Québec, Canada (A.F.T.). alexis.turgeon@fmed.ulaval.ca (Accepted for publication December 4, 2020. Published online first on January 6, 2021.) Anesthesiology April 2021, Vol. 134, 666–667. https://doi.org/10.1097/ALN.0000000000003667 Connected Content Commentary: Perioperative Use of Gabapentinoids: Comment Commentary: Perioperative Use of Gabapentinoids: Comment Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Share Icon Share Facebook Twitter LinkedIn Email Cite Icon Cite Get Permissions Search Site Citation Michael Verret, Ryan Zarychanski, François Lauzier, Alexis F. Turgeon; Perioperative Use of Gabapentinoids: Reply. Anesthesiology 2021; 134:666–667 doi: https://doi.org/10.1097/ALN.0000000000003667 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search nav search search input Search input auto suggest search filter All ContentAll PublicationsAnesthesiology Search Advanced Search We thank Dr. Araujo1 for his interest on our systematic review about the perioperative use of gabapentinoids for the management of postoperative acute pain.2 The main purpose of a systematic review with meta-analyses is to synthesize treatment effects considering all available data. By pooling data from different trials, the power to detect a differential effect is increased. Trials included in a systematic review frequently present some degree of clinical heterogeneity. However, not considering these trials in pooled analyses, as suggested by Dr. Araujo, would diminish our collective ability to both answer important research questions and understand the modifiers of important treatment effects. In our systematic review, we carefully considered potential sources of clinical heterogeneity among the included trials. First, we performed subgroup analyses to explore whether clinical heterogeneity or methodologic aspects of included trials could... Copyright © 2021, the American Society of Anesthesiologists, Inc. All Rights Reserved.2021 You do not currently have access to this content.