Abstract
The aim of this study was to determine the effect of etoricoxib 60 mg on tooth sensitivity (TS) caused by in-office bleaching. A triple-blind, parallel design, randomized clinical trial was conducted on 30 healthy, young adults who received either a placebo or etoricoxib. The drugs were administered 1 h before the bleaching process and after 24 h. Treatment was performed with 35 % hydrogen peroxide gel. The TS was recorded on three scales: VAS, 0-4, and 0-100. Shade evaluations were performed before and 30 days after bleaching with a visual shade guide and a spectrophotometer. The percentage of patients who reported TS at least once during treatment and the TS intensity were evaluated by Fisher's exact and Mann-Whitney U tests, respectively. Tooth color changes were evaluated by repeated measures ANOVA. There were no significant differences in the percentage of patients with TS, intensity of TS, and color between the groups. The anti-inflammatory medication etoricoxib 60 mg was unable to reduce the presence and intensity of TS. NCT01300780 (protocol No. 17838/2010).
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