Abstract
Background and objectivesRetroperitoneal liposarcoma (RPLS) are common soft tissue sarcomas of adulthood. The aim of this study is to show resectability of even giant liposarcomas and to identify factors associated with recurrence and survival in primary retroperitoneal liposarcomas.MethodsWe retrospectively reviewed the records of patients with retroperitoneal liposarcoma. Seventy-seven patients met inclusion criteria. Out of these 10 patients with primary giant, dedifferentiated retroperitoneal liposarcomas were operated with en bloc compartment resection with intention of radical resection. Treatment consisted of neoadjuvant radiochemotherapy and surgical resection or surgical resection.ResultsIn 6 patients, neoadjuvant radiochemotherapy was performed; 3 patients were treated with surgical resection alone and 1 patient received adjuvant chemotherapy. The median diameter of tumor size was 360 mm (300 to 440 mm). Operative outcome showed complete resection in all 10 patients. Local tumor free survival was in median 19 month. Tumor recurrence was seen in 3 of 4 patients (75%) without neoadjuvant radiochemotherapy, and in 2 of 6 patients (33%) after neoadjuvant radiochemotherapy in 2 years follow-up.ConclusionEven in case of giant retroperitoneal liposarcoma, complete resection is possible and remains the principal treatment. The rate of recurrence was improved in patients with neoadjuvant radiochemotherapy.
Highlights
Liposarcomas are neoplasms of mesodermic origin derived from adipose tissue
The objective of this study is to show the actual treatment and experience in the treatment of patients with giant dedifferentiated retroperitoneal liposarcoma in combination with neoadjuvant radiochemotherapy
Study cohort In the defined time period, 77 patients were identified with primary retroperitoneal liposarcoma
Summary
Liposarcomas are neoplasms of mesodermic origin derived from adipose tissue. It is the most common tumor entity of the retroperitoneum but represents less than 1% of all malignant tumors [1]. Retroperitoneal soft tissue sarcomas account for about 15% of all soft tissue sarcomas [2]. The two most common retroperitoneal types are well-differentiated (WDLPS) and high-grade dedifferentiated (DDLPS) liposarcomas [3]. The average diameter of the tumor is 20–25 cm with a weight of 15 to 20 kg [4]. Bachmann et al World Journal of Surgical Oncology (2020) 18:296. Retroperitoneal liposarcoma (RPLS) are common soft tissue sarcomas of adulthood. The aim of this study is to show resectability of even giant liposarcomas and to identify factors associated with recurrence and survival in primary retroperitoneal liposarcomas
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