Perioperative hypothalamic pituitary adrenal function in patients with silent corticotroph adenomas.

Abstract

Silent corticotroph adenomas (SCAs) are characterized by strong ACTH immunostaining without clinical manifestations of hypercortisolism. Patients with SCAs often present with mechanical symptoms related to tumor growth. This study investigates the hypothalamic pituitary adrenal axis (HPA) characteristics after adenomectomy in patients with SCAs. Biochemical parameters of HPA function were monitored frequently after surgical resection of non-functioning macroadenomas. Levels of ACTH, cortisol, DHEA and DHEA-S were measured frequently for 48h after adenomectomy. HPA data of patients with SCAs (n = 38) were compared to others (Controls) with non-secreting, ACTH-negative immunostaining adenomas of similar age and gender distribution (n = 182) who had adenomectomy. Plasma ACTH increased (P < 0.0001) equally in patients with SCA and controls reaching a peak at 3h (238 ± 123 vs. 233 ± 96ng/L, respectively) after extubation declining thereafter to baseline values 24-36h. Similarly, serum cortisol levels increased (P < 0.0001) equally in both groups reaching a maximum at 7h (36.8 ± 13.9 vs. 39.3 ± 13.3ug/dL). Serum DHEA also increased (P < 0.001) equally in both groups in parallel to the rise in serum cortisol. Serum DHEA-S levels similarly increased (P < 0.001) from their respective baseline (105.9 ± 67.5 and 106.5 ± 58.7ug/dL) reaching their peak (154.5 ± 69.5 and 153.5 ± 68.6ug/dL; respectively) at 15h after extubation. None of the patients acquired any hormone deficits. Under the maximal stimulation of the peri-operative stress, HPA function in patients with SCA behaved in an identical manner to others with ACTH-negative macroadenomas. Thus, despite the strong ACTH-positive immunostaining of these tumors, SCAs are truly non- functional.