Perioperative Drug Reactions in Cystic Fibrosis Lung Transplant Recipients

Abstract

Cystic fibrosis (CF) is one of the leading indications for bilateral sequential lung transplantation at the end stage of the disease. The association between cystic fibrosis and an increased predilection to atopic drug reactions is poorly understood. Little current information exists on the potential risk of atopic CF patients in the perioperative transplantation period compared with nonatopic CF patients. This study reviewed whether CF patients with a history of allergic disease who undergo lung transplantation may be at any increased risk for adverse reactions to drugs and blood products given intraoperatively and postoperatively. Our review of the 37 CF patients who underwent lung transplantation between January 1988 to mid 1997, at Stanford University Medical Center indicates for the first time that a history of allergic bronchopulmonary aspergillosis (ABPA) may be a risk factor for adverse drug reactions in the perioperative period, whereas atopy with allergen avoidance does not place the CF patient ...