Abstract
Perioperative Complications and Long-Term Outcome of Salvage Radical Prostatectomy Compared to Primary Radical Prostatectomy
Highlights
Prostate cancer is the most common malignancy in men and the third most common cause of cancer related death [1,2]
Salvage rPx after external beam radiotherapy (EBRT), BT or high intensity focused ultrasound (HIFU) is a feasible and valuable option for a well-informed individual patient and can lead to a significant biochemical recurrence (BCR)-free survival
Regarding the poor results of cancer control, we have to realize that failure after EBRT and BT is obviously detected too late and is associated with a mostly poor differentiated prostate cancer
Summary
Prostate cancer is the most common malignancy in men and the third most common cause of cancer related death [1,2]. Monitoring serum prostate specific antigen (PSA) after treatment of localized prostate cancer (PC) was routinely done to detect early disease. It leads to the identification of men with a PSA-only (biochemical) recurrence after definitive treatment for localized disease, usually without the appearance of signs or symptoms of either loco regional recurrence or distant metastasis disease. Following primary treatment with radiation therapy, 30% of patients developed a disease recurrence with a rising serum PSA [6]. 72% of these patients with recurrence after external radiation therapy will have locally recurrent disease [5]. Recurrence with an increasing PSA is a significant risk factor for subsequent metastatic progression and cancer specific mortality [3,5,7]. The data of CaPSURE database showed that only 2% of these patients were subsequently treated with salvage radical prostatectomy (rPx) [9]
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