Abstract
Aims: This study aimed to investigate the relationship between perioperative change in neutrophil count and survival of patients with esophageal squamous cell carcinoma. Method: Neutrophil change (Nc) (whereNc=post-surgeryneutrophil count-pre-surgeryneutrophil count) was counted according to data within 1week before surgery and 2weeks after surgery. Patients were divided into two groups, Nc ≥2.60 and Nc <2.60, according to the median of Nc. Results: Multivariate analysis revealed that Nc≥2.60 was an independent prognostic marker for overall survival. Subgroup analysis suggested that the overall survivalof male patients, patientsaged ≤60 years, patients without vessel invasion and patients without nerve infiltration wasdramatically worse for those with Nc<2.60. Conclusion: Perioperative change in neutrophil count predicts worse survival in esophageal squamous cell carcinoma after surgery.
Highlights
Numerous studies reported the prognostic significance of neutrophil count in patients with esophageal squamous cell carcinoma (ESCC), while the relationship between perioperative change in neutrophil count and survival of patients with ESCC after surgery has not been assessed
Six parameters including neutrophil change(Nc)(≥ 2.60 vs.
Multivariate analysis revealed that neutrophil change(Nc)(≥ 2.60 vs.
Summary
Numerous studies reported the prognostic significance of neutrophil count (or preferably NLR) in patients with esophageal squamous cell carcinoma (ESCC), while the relationship between perioperative change in neutrophil count and survival of patients with ESCC after surgery has not been assessed
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