Abstract

Abstract Introduction Cytoreductive surgery with hyperthermic intraoperative chemotherapy (HITHOC) is a therapeutic option for treatment of malignant pleural mesothelioma. Anaesthetic management might be challenging. Patients and methods A descriptive analysis of a case series is presented. Seven patients with malignant pleural mesothelioma diagnostic undergoing HITHOC surgery were studied. Combined general and epidural anaesthesia were administered. An intensive haemodynamic monitorization was implemented. Data regarding perioperative course was analyzed. Results Between May 2015 and October 2018 7 patients underwent HITHOC procedure. Blood transfusions were administered in all patients, and 5 of the 7 patients required vasoactive drug administration. Extubation at the end of the procedure was able in 6 of the 7 patients. The median length of stay in ICU was 4 days, and 29 days for the whole hospitalary stay. No significant postoperative pain was observed. Conclusions HITHOC surgery is a complex procedure in which several haemodynamic changes occur. An intensive intraoperative monitorization was useful for controlling complications.

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