Abstract
Introduction It is now thought that periodontal disease is a specifically combined infection of polymicrobial Gram-negative anaerobic bacteria, including Porphyromonas. gingivalis, Treponema denticola and Tunnerella forsythia, and Aggregatibactor actinomycetemcomitans, all of which have b
Highlights
It is thought that periodontal disease is a combined infection of polymicrobial Gram-negative anaerobic bacteria, including Porphyromonas. gingivalis, Treponema denticola and Tunnerella forsythia, and Aggregatibactor actinomycetemcomitans, all of which have been proposed as predominant pathogens, exclusively or synergistically with other bacteria, including Prevotella intermedia, Campylobacter rectus, Fusobacterium nucleatum and herpes virus
Monoclonal antibody specific to a bacterial antigen could prove to be an effective mode of passive immunization against P. gingivalis and possibly other periodontopathic bacteria
To prevent colonization of periopathogens, vaccination may be an important adjunctive therapy to mechanical debridement in humans, but extensive research in this direction may hold a promising future in development of periodontal vaccines
Summary
It is thought that periodontal disease is a combined infection of polymicrobial Gram-negative anaerobic bacteria, including Porphyromonas. gingivalis, Treponema denticola and Tunnerella forsythia, and Aggregatibactor actinomycetemcomitans, all of which have been proposed as predominant pathogens, exclusively or synergistically with other bacteria, including Prevotella intermedia, Campylobacter rectus, Fusobacterium nucleatum and herpes virus. Local passive immunization with rabbit antiserum against P. gingivalis hemagglutinin has infact resulted in a reduced colonization by exogenous P. gingivalis in the subgingival area over a 3-week period.[18] A cDNA fragment of P. gingivalis major fimbrial protein (fimA) was cloned into a plant expression vector When this chimeric plasmid was transferred into potato (Solanum tuberosum) cells, the ctb-fimA cDNA fragment was detectable in its genome.[19] monoclonal antibody specific to a bacterial antigen could prove to be an effective mode of passive immunization against P. gingivalis and possibly other periodontopathic bacteria. A genetically engineered mouse system developed recently may prove useful for the study of periodontal disease
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