PERIODONTAL THERAPY AFFECTS ORAL COLONIZATION OF CANDIDA SPP AND HIV INFECTION STATUS IN PATIENTS WITH PERIODONTITIS

Abstract

Objectives This study investigated the effect of nonsurgical periodontal therapy (NSPT) on the clinical and immunologic profile and oral colonization of Candida spp in patients infected with human immunodeficiency virus (HIV) and chronic periodontitis (CP). Study Design HIV-infected (test group) and non–HIV-infected (control group) adults patients with CP were selected. Gingival index (GI), probing depth (PD), clinical attachment level (CAL), number of teeth, CD4+ T lymphocytes and viral load, salivary interleukin (IL)-6, IL-8, and tumor necrosis factor-alpha (TNF-α), and Candida spp count were analyzed at baseline, 30, and 90 days after NSPT. Results Twenty-two patients infected with HIV and 20 patients not infected with HIV were evaluated. Candida spp count and salivary IL-6, IL-8, and TNF-α levels were higher in the test group than in the control group. Both groups presented decrease in Candida spp oral count, GI, PD, IL-6, and IL-8 as well as gain of CAL after NSPT at 30 and 90 days. In addition, patients from test group showed an increase of CD4+ T lymphocytes and a decrease of viral load. Conclusions NSPT had a beneficial effect on the clinical parameters of CP and on the Candida spp oral count and salivary levels of IL-6 and IL-8 in both groups, and also on the HIV-infection status. This study investigated the effect of nonsurgical periodontal therapy (NSPT) on the clinical and immunologic profile and oral colonization of Candida spp in patients infected with human immunodeficiency virus (HIV) and chronic periodontitis (CP). HIV-infected (test group) and non–HIV-infected (control group) adults patients with CP were selected. Gingival index (GI), probing depth (PD), clinical attachment level (CAL), number of teeth, CD4+ T lymphocytes and viral load, salivary interleukin (IL)-6, IL-8, and tumor necrosis factor-alpha (TNF-α), and Candida spp count were analyzed at baseline, 30, and 90 days after NSPT. Twenty-two patients infected with HIV and 20 patients not infected with HIV were evaluated. Candida spp count and salivary IL-6, IL-8, and TNF-α levels were higher in the test group than in the control group. Both groups presented decrease in Candida spp oral count, GI, PD, IL-6, and IL-8 as well as gain of CAL after NSPT at 30 and 90 days. In addition, patients from test group showed an increase of CD4+ T lymphocytes and a decrease of viral load. NSPT had a beneficial effect on the clinical parameters of CP and on the Candida spp oral count and salivary levels of IL-6 and IL-8 in both groups, and also on the HIV-infection status.