Periodontal disease and resistance factor. I. Immunopathological study for detection of antibiotic factors in the pocket fluid (author's transl)

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This study was made to clarify the existense of antibiotic factors to oral bacteria in the gingival pocket fluid of individuals with periodontal disease by using fluorescent antibody techniques. Fluorescein-labeled antisera were obtained from human oral bacteria, Clq, C3, properdin, IgG, IgA, IgM, IgD, IgE, Fab, fibrinogen, and serious frozen sections were stained by them.The results were as follows:1) Each substance was detcted in the bacterial mass as showing Table 1 and Fig. 1.2) IgG, IgA, Fab, and fibrinogen were demonstrated most frequently as Fig. 3.From above results, we arrived at following conclusions:1) Main defensive system to the oral bacteria in the gingival pocket were immunoglobulins and activated complement system.2) The complement was the alternative pathway in addition to classical pathway.3) We were suggested that both complement systems raised to activity of phagocytosis, and finally caused to bacterial lysis in the gingival pocket.