Abstract
Periodontitis is a chronic infectious disease that destroys periodontal supportive tissues and eventually causes tooth loss. It is attributed to microbial and immune factors. The goal of periodontal therapy is to achieve complete alveolar bone regeneration while keeping inflammation well-controlled. To reach this goal, many single or composite biomaterials that produce antibacterial and osteogenic effects on periodontal tissues have been developed, which are called bifunctional biomaterials. In this review, we summarize recent progress in periodontal bifunctional biomaterials including bioactive agents, guided tissue regeneration/guided bone regeneration (GTR/GBR) membranes, tissue engineering scaffolds and drug delivery systems and provide novel perspectives. In conclusion, composite biomaterials have been greatly developed and they should be chosen with care due to the risk of selection bias and the lack of evaluation of the validity of the included studies.
Highlights
Biomaterials: Progress and Periodontitis is a common chronic infectious disease, and severe periodontitis affects10.8% of the population in the world [1]
The generally accepted pathogenesis is an imbalance of oral symbiotic microbial groups, along with host immune defense [4]
The purpose of this review is to summarize antibacterial and osteogenic performances, and advantages and limitations of different bifunctional biomaterials, and to provide novel perspectives for further study
Summary
Biomaterials: Progress and Periodontitis is a common chronic infectious disease, and severe periodontitis affects. It causes irreversible damage to periodontal soft and hard tissues, including alveolar bone. The accumulation of bacteria related to periodontitis hinders tissue healing and regeneration processes [7,8]. The purpose of periodontal therapy is to realize periodontal tissue regeneration after controlling inflammation via infection clearance [13]. To reach this goal, bioactive materials with antibacterial and osteogenic properties are in constant evolution. Bioactive materials with antibacterial and osteogenic properties are in constant evolution They are classified as bioactive agents, guided tissue regeneration/guided bone regeneration (GTR/GBR). Membranes, tissue engineering scaffolds and drug delivery systems according to different patterns of action.
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