Abstract
Many hormones must be delivered in a periodic, pulsatile manner to exert their physiological effect. Similarly, periodic pulses of cyclic AMP control the development of the amebae of the slime mold Dictyostelium discoideum, a system that provides insight into the function of pulsatile patterns of hormone secretion. In both instances, periodic signaling represents an optimal mode of intercellular communication that allows for maximum responsiveness where constant stimuli bring desensitization.
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