Periodic Paralyses

Abstract

Event Abstract Back to Event Periodic Paralyses Matthew McCoyd1* 1 Loyola University Health System, Department of Neurology, United States Learning objectives: Discuss relevant muscle physiology and ion channel properties in disease Differentiate the primary and secondary periodic paralyses Understand diagnostic and treatment options for the periodic paralyses The periodic paralyses are a heterogeneous group of disorders characterized by episodic muscle weakness. The weakness is often seen in conjunction with altered serum potassium levels (hyperkalemic and hypokalemic periodic paralysis). The physiologic basis of the weakness in these disorders is altered muscle membrane excitability due to defective membrane ion channels. These weakening conditions can be divided into primary and secondary disorders. The primary periodic paralyses are a group of inherited disorders in which mutations cause structural changes within channel proteins, specifically sodium, potassium and calcium channels, leading to aberrant depolarization and weakness. However, weakness is only one manifestation of the responsible gene defects. Symptoms can also include myotonia, stiffness and pain. The reason for variability in phenotypic expression despite genotypic similarity is not clear at this time. The goal of this discussion is to review basic muscle physiology with a focus on the relevant ion channels, review the distinguishing clinical features of the ion channel mutations, and consider diagnostic and treatment options in the disorders characterized by periodic paralysis. Conference: Paroxysmal Neurology Symposium, Chicago, United States, 7 Apr - 7 Apr, 2010. Presentation Type: Oral Presentation Topic: Abstracts Citation: McCoyd M (2010). Periodic Paralyses. Front. Neurol. Conference Abstract: Paroxysmal Neurology Symposium. doi: 10.3389/conf.fneur.2010.07.00005 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 07 Apr 2010; Published Online: 07 Apr 2010. * Correspondence: Matthew McCoyd, Loyola University Health System, Department of Neurology, Maywood, IL, United States, mmccoyd@lumc.edu Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Matthew McCoyd Google Matthew McCoyd Google Scholar Matthew McCoyd PubMed Matthew McCoyd Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.