Periodic leg movements during sleep in PLMD and RLS patients with and without pramipexole treatment

Abstract

Objective Pharmacological treatment of restless legs syndrome (RLS) patients with pramipexole (PPX) is common and evidence based, whereas the effect of pramipexole on periodic leg movements (PLM) in periodic limb movement disorder (PLMD) patients is unknown. The aim of this study was to investigate the effect of pramipexole on sleep parameters and PLM indices in RLS and in PLMD patients.