Perio Protect™ Treatment of Chronic Periodontitis Reduces Biofilm and Inflammation

Abstract

Periodontal health exists when a small numbers of predominantly Gram-positive aerobes, with fewer Gram-positive facilitative and a small number of obligate anaerobes live supragingival and subgingival in sulci less than 3 mm. The biofilm and host cohabitate in a commensal or mutualistic relationship without a host inflammatory response. Periodontal disease occurs when there is a shift in critical wound composition of the periodontal subgingival microbiome associated with host micro-environment changes. The oxygen saturation decreases, and an imbalance (dysbiosis) occurs where the more virulent anaerobic pathogenic microorganisms predominate at the expense of aerobic commensal microorganisms, fostering a chronic wound, resulting in an inflammatory immune response. Existing treatments focus on controlling plaque but fail to manage the immune inflammatory reaction. The Perio Protect Method™ manages plaque and inflammation through subgingival delivery of 1.7% hydrogen peroxide (Perio Gel™) and antioxidants. Perio Trays™ are FDA cleared medical devices manufactured with customized seals and extensions which compress the wound and overcome crevicular flow and deliver medications better than other dental appliances to the source of the dental infection. Perio Gel™ generates 5.3 X oxygen saturation in the Perio Tray™ comparable to the oxygen saturation in a hyperbaric chamber. Thr Perio Protect Method™ manages obligate anaerobes, accelerates tissue recovery, healing, and repair, establishes a microenvironment reversing dysbiosis, and improves systemic LpPLA2 and hs-CRP levels. The numbers of virulent facultative and obligate anaerobes decrease and are replaced with fewer aerobic bacteria found in healthy tissues. Anti-inflammatory medications neutralize the host inflammatory response, decrease tissue damages, and augment osteogenic improvements. Managing periodontal inflammation is medically important because emerging evidence demonstrates a strong relationship between periodontal inflammation and numerous systemic conditions including, but not limited to, atherosclerosis, stroke, Alzheimer’s disease, type 2 diabetes, obesity, and rheumatoid arthritis. A common link in these systemic conditions with periodontitis is an increased systemic inflammatory burden, which exacerbates other co-existing inflammatory conditions leading to related diseases. Treatments convert the microenvironment from disease to health (reverse dysbiosis) and address both the etiology (biofilm) and the inflammatory host responses. The Perio Protect Method™ is a treatment regimen that becomes a long-term periodontal homecare system.