Abstract
Progesterone was administered to rats perinatally via either maternal Silastic implants (Experiment 1) or daily maternal injections (Experiment 2). Animals were tested at 14 days of age on an active avoidance task (Experiments 1 and 2), and in adulthood on a Lashley III maze task, active and passive avoidance tasks, and open field activity (Experiment 1) and on social and reproductive behavior measures (Experiment 2). Adult males' performance on the Lashley III task was significantly impaired by progesterone treatment in Experiment 1 as were male copulatory and aggressive behaviors in Experiment 2. Perinatal progesterone as administered in these experiments does not results in an animal model for the reported enhancement of human performance consequent to prenatal progesterone treatment. It is, however, consistent with an interpretation of demasculinization of behavior patterns.
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