PERINATAL OUTCOMES IN CHILDREN BORN AFTER PREIMPLANTATION GENETIC TESTING- FOR ANEUPLOIDY (PGT-A): DOES THE TECHNIQUE HAVE AN EFFECT?

Abstract

To analyze the effect of the PGT-A technique in the birthweight, length, delivery mode and gestational age of newborns from donor oocytes. This retrospective study involves couples underwent a cryo-embryo transfer from January 2019 to March 2020, which resulted in a singleton born. Perinatal outcomes from a total of 147 children born from day 5-6 blastocyst without PGT-A (N=65) were compared to those born from day 5-6 euploid blastocysts after PGT-A (N=82). The origin of the oocytes in both groups were young donors (fresh and/or vitrified oocytes) and only cycles where one gestational sac, and consequently a singleton born, were included. Data collected include the weight and length of the donor gametes, type of oocytes (fresh and/or vitrified), mother’s body mass index (BMI) and gestational weeks and were used to adjust the statistical results. All analyses were conducted using SPSS software. P<0,05 was considered statistically significant. No significantly differences were found between the group with PGT-A and those without PGT-A for the following variable, respectively: mother’s age (43.07±0.54 versus 42.58±0.44 years), mother’s BMI (23.27±0.45 versus 23.91±0.44), oocyte donor weight (61.02±1.11 versus 60.21±1.32 kgs), oocyte donor length (162.93±0.72 versus 164.03±0.89 cm), sperm donor/partner weight (84.00±1.52 versus 86.02±1.59 kgs) and sperm donor/partner length (181.45±0.78 versus 179.86±1.06 cm). For children coming from cycles with and without PGT-A carried out, respectively, the mean birthweight was 3140.32±65.98 versus 3054±69.04 gr., (P=0.37) mean length was 49.63±0.46 versus 48.90±0.65 cm (P=0.34) and gestational age was 37.96±0.23 versus 37.70±0.26 weeks (P=0.46), respectively. Related to the delivery mode, in the PGT-A group, 60.98% (50/82) of children were born after caesarean section and 39.02% (32/82) were spontaneous or instrumental deliveries; in the group without PGT-A, these data were 69.23% (45/65) and 30.77% (20/65) respectively, not finding significant differences (P>0,05). The results obtained for preterm births (<37 weeks of pregnancy) after performing or not PGT-A, respectively, were 10.98% (9/82) versus 21.54% (14/65); P>0.05. No significantly differences were found in birthweight, length and gestational age in children born after biopsied embryos and cryopreserved not-biopsied embryos. Furthermore, the proportion of caesarean section and spontaneous or instrumental deliveries were comparable between both groups. Also, preterm births between groups were not significantly different, despite finding higher number of preterm cases in embryos without PGT-A.