Abstract
Preterm birth is defined as all births before 37 completed weeks of gestation. Preterm birth can be further sub-divided based on gestational age: extremely preterm (<28 weeks), very preterm (28 to <32 weeks) and moderate preterm (32 to <37 weeks). Retrospective observational case–control study review (1 year i.e., 2015) is to assess pregnancy outcome among women with gestational diabetes mellitus (GDM) delivering very preterm (28 + 0/7 to 31 + 6/7 weeks of gestation). The study group included all women diagnosed with GDM and were compared to a control group of women delivering at the same gestational age period but without GDM. In all, 30 women were included in the study, of whom 15 were diagnosed with GDM and 15 were not. All women had a cesarean delivery. Neonates of mothers with GDM had higher ponderal index. Birth weight had the positive associations with blood glucose of newborn (r = 0.37, p = 0.047) and term of births (r = 0.52, p = 0.003). Birth weight had the negative associations with maternal systolic pressure (r = −0.7, p < 0.05), pre-eclampsia (r = −0.6, p < 0.05) and maternal pre-pregnancy body mass index (r = −0.5, p < 0.05). There were no differences in mortality or other parameters for neonatal morbidity, including bronchopulmonary dysplasia, prematurity retinopathy, neonatal anemia. According to our data, very preterm delivery occurring in women with GDM does not confer an increased risk for neonatal complications.
Highlights
Preterm birth, defined as childbirth occurring at less than 37 completed weeks or 259 days of gestation, is a major determinant of neonatal mortality and morbidity and has longterm adverse consequences for health [1,2,3,4]
The study group included all women diagnosed with gestational diabetes mellitus (GDM) and were compared to a control group of women delivering at the same gestational age period but without GDM
The study group included all women diagnosed with GDM and were compared to a control group of women delivering at the same gestational age period but without known GDM
Summary
Preterm birth, defined as childbirth occurring at less than 37 completed weeks or 259 days of gestation, is a major determinant of neonatal mortality and morbidity and has longterm adverse consequences for health [1,2,3,4]. Preterm birth can be further sub-divided based on gestational age: extremely preterm (528 weeks), very preterm (28 to 532 weeks) and moderate preterm (32 to 537 completed weeks of gestation) [2]. Of all early neonatal deaths that are not related to congenital malformations, 28% are due to preterm birth [1]. The morbidity associated with preterm birth often extends to later life, resulting in enormous physical, psychological and economic costs [1,2]. The severity of complications associated with prematurity is proportional to the gestational age. Preterm birth rates have been reported to range from 5% to 11.6% of live births [1,5,6]
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